Blending modes behave differently depending on whether you are in object mode or image edit mode. In object mode, a blending mode affects the selected object.
In image edit mode, blending mode behaves in these ways:
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A blending mode affects the floating selection of pixels. |
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A blending mode affects the brushes and fills of subsequently drawn pixels when there is not a floating selection. |
For more information on blending modes, see Understanding blending modes.